| 2010 AFC Yearly Schedule/Results |
| (All Times Eastern) |
| |
| Sunday, September 12 |
| Atlanta at Pittsburgh, 1:00 PM | Preview | Matchup | Log | Wrap | Box |
| Miami at Buffalo, 1:00 PM | Preview | Matchup | Log | Wrap | Box |
| Oakland at Tennessee, 1:00 PM | Preview | Matchup | Log | Wrap | Box |
| Indianapolis at Houston, 1:00 PM | Preview | Matchup | Log | Wrap | Box |
| Denver at Jacksonville, 1:00 PM | Preview | Matchup | Log | Wrap | Box |
| Cincinnati at New England, 1:00 PM | Preview | Matchup | Log | Wrap | Box |
| Cleveland at Tampa Bay, 1:00 PM | Preview | Matchup | Log | Wrap | Box |
| |
| Monday, September 13 |
| Baltimore at NY Jets, 7:00 PM | Preview | Matchup | Log | Wrap | Box |
| San Diego at Kansas City, 10:15 PM | Preview | Matchup | Log | Wrap | Box |
| |
| Sunday, September 19 |
| Baltimore at Cincinnati, 1:00 PM |
| Miami at Minnesota, 1:00 PM |
| Buffalo at Green Bay, 1:00 PM |
| Kansas City at Cleveland, 1:00 PM |
| Pittsburgh at Tennessee, 1:00 PM |
| Seattle at Denver, 4:05 PM |
| St. Louis at Oakland, 4:05 PM |
| Jacksonville at San Diego, 4:15 PM |
| New England at NY Jets, 4:15 PM |
| Houston at Washington, 4:15 PM |
| NY Giants at Indianapolis, 8:20 PM |
| |
| Sunday, September 26 |
| Cincinnati at Carolina, 1:00 PM |
| Buffalo at New England, 1:00 PM |
| San Francisco at Kansas City, 1:00 PM |
| Tennessee at NY Giants, 1:00 PM |
| Cleveland at Baltimore, 1:00 PM |
| Dallas at Houston, 1:00 PM |
| Pittsburgh at Tampa Bay, 1:00 PM |
| Philadelphia at Jacksonville, 4:05 PM |
| San Diego at Seattle, 4:15 PM |
| Indianapolis at Denver, 4:15 PM |
| Oakland at Arizona, 4:15 PM |
| NY Jets at Miami, 8:20 PM |
| |
| Sunday, October 03 |
| NY Jets at Buffalo, 1:00 PM |
| Denver at Tennessee, 1:00 PM |
| Cincinnati at Cleveland, 1:00 PM |
| Baltimore at Pittsburgh, 1:00 PM |
| Indianapolis at Jacksonville, 4:05 PM |
| Houston at Oakland, 4:05 PM |
| Arizona at San Diego, 4:15 PM |
| |
| Monday, October 04 |
| New England at Miami, 8:30 PM |
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| Sunday, October 10 |
| Tampa Bay at Cincinnati, 1:00 PM |
| NY Giants at Houston, 1:00 PM |
| Atlanta at Cleveland, 1:00 PM |
| Denver at Baltimore, 1:00 PM |
| Kansas City at Indianapolis, 1:00 PM |
| Jacksonville at Buffalo, 1:00 PM |
| Tennessee at Dallas, 4:15 PM |
| San Diego at Oakland, 4:15 PM |
| |
| Monday, October 11 |
| Minnesota at NY Jets, 8:30 PM |
| |
| Sunday, October 17 |
| San Diego at St. Louis, 1:00 PM |
| Kansas City at Houston, 1:00 PM |
| Baltimore at New England, 1:00 PM |
| Miami at Green Bay, 1:00 PM |
| Cleveland at Pittsburgh, 1:00 PM |
| Oakland at San Francisco, 4:05 PM |
| NY Jets at Denver, 4:05 PM |
| Indianapolis at Washington, 8:20 PM |
| |
| Monday, October 18 |
| Tennessee at Jacksonville, 8:30 PM |
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| Sunday, October 24 |
| Jacksonville at Kansas City, 1:00 PM |
| Philadelphia at Tennessee, 1:00 PM |
| Buffalo at Baltimore, 1:00 PM |
| Cleveland at New Orleans, 1:00 PM |
| Cincinnati at Atlanta, 1:00 PM |
| Pittsburgh at Miami, 1:00 PM |
| New England at San Diego, 4:15 PM |
| Oakland at Denver, 4:15 PM |
| |
| Sunday, October 31 |
| Buffalo at Kansas City, 1:00 PM |
| Denver at San Francisco, 1:00 PM |
| Miami at Cincinnati, 1:00 PM |
| Jacksonville at Dallas, 1:00 PM |
| Green Bay at NY Jets, 1:00 PM |
| Tennessee at San Diego, 4:05 PM |
| Minnesota at New England, 4:15 PM |
| Seattle at Oakland, 4:15 PM |
| Pittsburgh at New Orleans, 8:20 PM |
| |
| Monday, November 01 |
| Houston at Indianapolis, 8:30 PM |
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| Sunday, November 07 |
| NY Jets at Detroit, 1:00 PM |
| Miami at Baltimore, 1:00 PM |
| Chicago at Buffalo, 1:00 PM |
| New England at Cleveland, 1:00 PM |
| San Diego at Houston, 1:00 PM |
| Indianapolis at Philadelphia, 4:15 PM |
| Kansas City at Oakland, 4:15 PM |
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| Monday, November 08 |
| Pittsburgh at Cincinnati, 8:30 PM |
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| Thursday, November 11 |
| Baltimore at Atlanta, 8:20 PM |
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| Sunday, November 14 |
| NY Jets at Cleveland, 1:00 PM |
| Cincinnati at Indianapolis, 1:00 PM |
| Detroit at Buffalo, 1:00 PM |
| Tennessee at Miami, 1:00 PM |
| Houston at Jacksonville, 1:00 PM |
| Kansas City at Denver, 4:05 PM |
| New England at Pittsburgh, 8:20 PM |
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| Thursday, November 18 |
| Chicago at Miami, 8:20 PM |
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| Sunday, November 21 |
| Buffalo at Cincinnati, 1:00 PM |
| Houston at NY Jets, 1:00 PM |
| Baltimore at Carolina, 1:00 PM |
| Washington at Tennessee, 1:00 PM |
| Oakland at Pittsburgh, 1:00 PM |
| Arizona at Kansas City, 1:00 PM |
| Cleveland at Jacksonville, 1:00 PM |
| Indianapolis at New England, 4:15 PM |
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| Monday, November 22 |
| Denver at San Diego, 8:30 PM |
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| Thursday, November 25 |
| New England at Detroit, 12:30 PM |
| Cincinnati at NY Jets, 8:20 PM |
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| Sunday, November 28 |
| Jacksonville at NY Giants, 1:00 PM |
| Tennessee at Houston, 1:00 PM |
| Tampa Bay at Baltimore, 1:00 PM |
| Carolina at Cleveland, 1:00 PM |
| Pittsburgh at Buffalo, 1:00 PM |
| Miami at Oakland, 4:05 PM |
| Kansas City at Seattle, 4:05 PM |
| St. Louis at Denver, 4:15 PM |
| San Diego at Indianapolis, 8:20 PM |
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| Thursday, December 02 |
| Houston at Philadelphia, 8:20 PM |
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| Sunday, December 05 |
| Cleveland at Miami, 1:00 PM |
| Denver at Kansas City, 1:00 PM |
| Buffalo at Minnesota, 1:00 PM |
| Jacksonville at Tennessee, 1:00 PM |
| New Orleans at Cincinnati, 1:00 PM |
| Oakland at San Diego, 4:05 PM |
| Dallas at Indianapolis, 4:15 PM |
| Pittsburgh at Baltimore, 8:20 PM |
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| Monday, December 06 |
| NY Jets at New England, 8:30 PM |
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| Thursday, December 09 |
| Indianapolis at Tennessee, 8:20 PM |
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| Sunday, December 12 |
| Cleveland at Buffalo, 1:00 PM |
| New England at Chicago, 1:00 PM |
| Cincinnati at Pittsburgh, 1:00 PM |
| Oakland at Jacksonville, 1:00 PM |
| Denver at Arizona, 4:15 PM |
| Miami at NY Jets, 4:15 PM |
| Kansas City at San Diego, 4:15 PM |
| |
| Monday, December 13 |
| Baltimore at Houston, 8:30 PM |
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| Thursday, December 16 |
| San Francisco at San Diego, 8:20 PM |
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| Sunday, December 19 |
| Cleveland at Cincinnati, 1:00 PM |
| Buffalo at Miami, 1:00 PM |
| Jacksonville at Indianapolis, 1:00 PM |
| New Orleans at Baltimore, 1:00 PM |
| Houston at Tennessee, 1:00 PM |
| Kansas City at St. Louis, 1:00 PM |
| NY Jets at Pittsburgh, 4:15 PM |
| Denver at Oakland, 4:15 PM |
| Green Bay at New England, 8:20 PM |
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| Thursday, December 23 |
| Carolina at Pittsburgh, 8:20 PM |
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| Sunday, December 26 |
| Detroit at Miami, 1:00 PM |
| Washington at Jacksonville, 1:00 PM |
| NY Jets at Chicago, 1:00 PM |
| Tennessee at Kansas City, 1:00 PM |
| Baltimore at Cleveland, 1:00 PM |
| New England at Buffalo, 1:00 PM |
| Indianapolis at Oakland, 4:05 PM |
| Houston at Denver, 4:05 PM |
| San Diego at Cincinnati, 8:20 PM |
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| Sunday, January 02 |
| Pittsburgh at Cleveland, 1:00 PM |
| Cincinnati at Baltimore, 1:00 PM |
| Tennessee at Indianapolis, 1:00 PM |
| Oakland at Kansas City, 1:00 PM |
| Jacksonville at Houston, 1:00 PM |
| Buffalo at NY Jets, 1:00 PM |
| Miami at New England, 1:00 PM |
| San Diego at Denver, 4:15 PM |
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