| AFC Injuries | | |
| Baltimore Ravens |
| Player | Pos. | Date | Details | Status | Injury |
| Lardarius Webb | CB | 09/09/2010 | is probable for Monday's game against the NY Jets | Probable | knee |
| Oniel Cousins | T | 09/09/2010 | is probable for Monday's game against the NY Jets | Probable | head |
| Paul Kruger | LB | 09/09/2010 | is questionable for Monday's game against the NY Jets | Questionable | shoulder |
| Ramon Harewood | T | 09/04/2010 | is on injured reserve | IR | knees |
| Stefan Rodgers | G | 09/04/2010 | is on injured reserve | IR | ankle |
| David Hale | G | 09/04/2010 | is on injured reserve | IR | tailbone |
| Kelly Talavou | DT | 09/04/2010 | is on injured reserve | IR | knee |
| Ed Reed | S | 09/04/2010 | is on the Physically-Unable-to-Perform-List | PUP | hip |
| Mike McLaughlin | FB | 09/01/2010 | is on injured reserve | IR | hip |
| Matt Lawrence | RB | 08/31/2010 | is on the Physically-Unable-to-Perform-List | PUP | knee |
| Terrence Cody | DT | 09/09/2010 | will miss Monday's game against the NY Jets | Out | knee |
| Daniel Sanders | C | 08/30/2010 | is on injured reserve | IR | shoulder |
| Marcus Paschal | CB | 08/30/2010 | is on injured reserve | IR | quadriceps |
| Donte Stallworth | WR | 08/28/2010 | is expected to miss two months | Out | foot |
| Brendon Ayanbadejo | LB | 08/31/2010 | is on the Physically-Unable-to-Perform-List | PUP | quadriceps |
| Jared Gaither | T | 08/16/2010 | is out indefinitely | Out | back |
| Domonique Foxworth | CB | 07/29/2010 | is on injured reserve | IR | knee |
| |
| Buffalo Bills |
| Player | Pos. | Date | Details | Status | Injury |
| Kawika Mitchell | LB | 09/10/2010 | is on injured reserve | IR | foot |
| Antonio Coleman | LB | 09/08/2010 | is questionable for Sunday's game against Miami | Questionable | hamstring |
| Reggie Torbor | LB | 09/10/2010 | will miss Sunday's game against Miami | Out | chest |
| Jon Corto | S | 07/29/2010 | is on the Physically-Unable-to-Perform-List | PUP | wrist |
| Joe Klopfenstein | TE | 07/22/2010 | is on injured reserve | IR | undisclosed |
| Danny Batten | LB | 08/22/2010 | is on injured reserve | IR | shoulder |
| Marcus Easley | WR | 08/22/2010 | is on injured reserve | IR | knee |
| Shawn Nelson | TE | 08/20/2010 | will be eligible to return on 10/10 against Jacksonville | Suspended | four-game suspension |
| Jairus Byrd | S | 09/08/2010 | is questionable for Sunday's game against Miami | Questionable | groin |
| |
| Cincinnati Bengals |
| Player | Pos. | Date | Details | Status | Injury |
| Jonathan Fanene | DT | 09/08/2010 | is questionable for Sunday's game against New England | Questionable | hamstring |
| Andre Caldwell | WR | 09/08/2010 | is questionable for Sunday's game against New England | Questionable | groin |
| Geno Atkins | DT | 09/09/2010 | is questionable for Sunday's game against New England | Questionable | knee |
| Brandon Ghee | CB | 09/08/2010 | is questionable for Sunday's game against New England | Questionable | head |
| Andrew Mitchell | T | 08/24/2010 | is on injured reserve | IR | knee |
| Gibril Wilson | S | 08/29/2010 | is on injured reserve | IR | knee |
| Cordera Eason | RB | 08/12/2010 | is on injured reserve | IR | foot |
| Tom Nelson | S | 08/30/2010 | is on the Physically-Unable-to-Perform-List | PUP | ankle |
| Brian Leonard | RB | 09/09/2010 | is doubtful for Sunday's game against New England | Doubtful | foot |
| Jason Shirley | G | 07/21/2010 | is on the Reserve/Non-Football Injury List | Out | Achilles |
| |
| Cleveland Browns |
| Player | Pos. | Date | Details | Status | Injury |
| Shawn Lauvao | G | 09/09/2010 | is questionable for Sunday's game against Tampa Bay | Questionable | ankle |
| Floyd Womack | G | 09/08/2010 | is questionable for Sunday's game against Tampa Bay | Questionable | knee |
| Robert Royal | TE | 09/08/2010 | is questionable for Sunday's game against Tampa Bay | Questionable | ankle |
| David Bowens | LB | 09/08/2010 | is questionable for Sunday's game against Tampa Bay | Questionable | knee |
| Marcus Benard | LB | 09/08/2010 | is questionable for Sunday's game against Tampa Bay | Questionable | shoulder |
| Nick Sorensen | S | 09/08/2010 | is doubtful for Sunday's game against Tampa Bay | Doubtful | concussion |
| D'Qwell Jackson | LB | 09/06/2010 | is out indefinitely | Out | pectoral |
| Shaun Rogers | DT | 09/08/2010 | is probable for Sunday's game against Tampa Bay | Probable | ankle |
| Montario Hardesty | RB | 09/03/2010 | is on injured reserve | IR | knee |
| Titus Adams | DL | 08/31/2010 | is on injured reserve | IR | leg |
| Johnathan Haggerty | WR | 08/16/2010 | is on injured reserve | IR | foot |
| Kwaku Danso | DL | 08/24/2010 | is on injured reserve | IR | finger |
| Dave Zastudil | P | 08/17/2010 | is on injured reserve | IR | knee |
| Chris Roberson | CB | 08/07/2010 | is on injured reserve | IR | leg |
| |
| Denver Broncos |
| Player | Pos. | Date | Details | Status | Injury |
| Demaryius Thomas | WR | 09/08/2010 | is probable for Sunday's game against Jacksonville | Probable | foot |
| Knowshon Moreno | RB | 09/08/2010 | is probable for Sunday's game against Jacksonville | Probable | hamstring |
| Andre Brown | RB | 09/08/2010 | is probable for Sunday's game against Jacksonville | Probable | toe |
| Darcel McBath | S | 09/08/2010 | is questionable for Sunday's game against Jacksonville | Questionable | forearm |
| Daniel Graham | TE | 09/09/2010 | is probable for Sunday's game against Jacksonville | Probable | chest |
| Marquez Branson | TE | 09/03/2010 | is out indefinitely | Out | knee |
| Ryan Harris | T | 09/08/2010 | is doubtful for Sunday's game against Jacksonville | Doubtful | ankle |
| LenDale White | RB | 09/04/2010 | is on injured reserve | IR | Achilles |
| Brandon Stokley | WR | 09/04/2010 | is on injured reserve | IR | groin |
| Elvis Dumervil | LB | 09/04/2010 | is on injured reserve | IR | pectoral |
| |
| Houston Texans |
| Player | Pos. | Date | Details | Status | Injury |
| Mario Williams | DE | 09/08/2010 | is questionable for Sunday's game against Indianapolis | Questionable | groin |
| Owen Daniels | TE | 09/08/2010 | is questionable for Sunday's game against Indianapolis | Questionable | knee |
| Duane Brown | T | 09/08/2010 | is questionable for Sunday's game against Indianapolis | Questionable | hamstring |
| Kareem Jackson | CB | 09/08/2010 | is probable for Sunday's game against Indianapolis | Probable | eye |
| Antwaun Molden | CB | 09/08/2010 | is questionable for Sunday's game against Indianapolis | Questionable | ankle |
| Steve Slaton | RB | 09/08/2010 | is probable for Sunday's game against Indianapolis | Probable | toe |
| Anthony Hill | TE | 09/03/2010 | is on the Physically-Unable-to-Perform-List | PUP | knee |
| Andre Davis | WR | 09/03/2010 | is on injured reserve | IR | tailbone |
| Trindon Holliday | WR | 08/30/2010 | is on injured reserve | IR | thumb |
| Darnell Bing | LB | 08/20/2010 | is on injured reserve | IR | neck |
| Ben Tate | RB | 08/16/2010 | is on injured reserve | IR | ankle |
| Brian Cushing | LB | 05/18/2010 | will be eligible to return on 10/10 against the NY Giants | Suspended | four-game suspension |
| Trey Stross | WR | 06/11/2010 | is on injured reserve | IR | undisclosed |
| |
| Indianapolis Colts |
| Player | Pos. | Date | Details | Status | Injury |
| Tony Ugoh | T | 09/08/2010 | is questionable for Sunday's game against Houston | Questionable | foot |
| Anthony Gonzalez | WR | 09/09/2010 | is questionable for Sunday's game against Houston | Questionable | back |
| Jeff Saturday | C | 09/08/2010 | is probable for Sunday's game against Houston | Probable | knee |
| Jacob Lacey | CB | 09/08/2010 | is questionable for Sunday's game against Houston | Questionable | head |
| Cody Glenn | LB | 09/08/2010 | is questionable for Sunday's game against Houston | Questionable | hamstring |
| Charlie Johnson | T | 09/08/2010 | is questionable for Sunday's game against Houston | Questionable | foot |
| Jamie Silva | S | 08/16/2010 | is on injured reserve | IR | knee |
| John Gill | DT | 08/09/2010 | is expected to miss the entire season | Out | personal/legal |
| Kevin Thomas | CB | 08/30/2010 | is on injured reserve | IR | knee |
| |
| Jacksonville Jaguars |
| Player | Pos. | Date | Details | Status | Injury |
| Jarett Dillard | WR | 09/10/2010 | will miss Sunday's game against Denver | Out | foot |
| Deji Karim | RB | 09/08/2010 | is questionable for Sunday's game against Denver | Questionable | thumb |
| Scotty McGee | KR | 09/08/2010 | is questionable for Sunday's game against Denver | Questionable | shoulder |
| Kyle Bosworth | LB | 09/04/2010 | is on injured reserve | IR | hamstring |
| D'Anthony Smith | DT | 08/31/2010 | is on injured reserve | IR | Achilles |
| John Estes | C | 08/31/2010 | is on injured reserve | IR | knee |
| Freddy Keiaho | LB | 08/20/2010 | is on injured reserve | IR | concussion |
| Bryan Smith | DE | 05/11/2010 | is on injured reserve | IR | knee |
| |
| Kansas City Chiefs |
| Player | Pos. | Date | Details | Status | Injury |
| Ryan O'Callaghan | T | 09/09/2010 | is questionable for Monday's game against San Diego | Questionable | groin |
| Cameron Sheffield | LB | 09/09/2010 | is questionable for Monday's game against San Diego | Questionable | neck |
| Jerheme Urban | WR | 09/04/2010 | is on injured reserve | IR | finger |
| Maurice Leggett | CB | 09/04/2010 | is on injured reserve | IR | neck |
| Tervaris Johnson | RB | 08/14/2010 | is on injured reserve | IR | knee |
| |
| Miami Dolphins |
| Player | Pos. | Date | Details | Status | Injury |
| Brandon Marshall | WR | 09/09/2010 | is probable for Sunday's game against Buffalo | Probable | ankle |
| Jake Grove | C | 09/08/2010 | is probable for Sunday's game against Buffalo | Probable | shoulder |
| Channing Crowder | LB | 09/09/2010 | is doubtful for Sunday's game against Buffalo | Doubtful | groin |
| Jake Long | T | 09/08/2010 | is questionable for Sunday's game against Buffalo | Questionable | knee |
| Will Allen | CB | 09/05/2010 | is on injured reserve | IR | knee |
| Nate Garner | T | 08/31/2010 | is on injured reserve | IR | foot |
| Phillip Merling | DE | 08/31/2010 | is on the Reserve/Non-Football Injury list | Out | Achilles |
| |
| New England Patriots |
| Player | Pos. | Date | Details | Status | Injury |
| Randy Moss | WR | 09/08/2010 | is probable for Sunday's game against Cincinnati | Probable | illness |
| Matthew Slater | WR | 09/08/2010 | is probable for Sunday's game against Cincinnati | Probable | hamstring |
| Myron Pryor | DE | 09/08/2010 | is probable for Sunday's game against Cincinnati | Probable | knee |
| Aaron Hernandez | TE | 09/08/2010 | is probable for Sunday's game against Cincinnati | Probable | knee |
| Brandon Deaderick | DE | 09/08/2010 | is probable for Sunday's game against Cincinnati | Probable | toe |
| Tom Brady | QB | 09/08/2010 | is probable for Sunday's game against Cincinnati | Probable | right shoulder |
| Terrence Wheatley | CB | 09/08/2010 | is questionable for Sunday's game against Cincinnati | Questionable | foot |
| Nick Kaczur | T | 09/08/2010 | is questionable for Sunday's game against Cincinnati | Questionable | back |
| Julian Edelman | WR | 09/09/2010 | is questionable for Sunday's game against Cincinnati | Questionable | foot |
| Ron Brace | DE | 09/08/2010 | is probable for Sunday's game against Cincinnati | Probable | ankle |
| Kyle Arrington | CB | 09/09/2010 | is probable for Sunday's game against Cincinnati | Probable | groin |
| Jermaine Cunningham | LB | 09/08/2010 | is probable for Sunday's game against Cincinnati | Probable | ankle |
| Laurence Maroney | RB | 09/09/2010 | is questionable for Sunday's game against Cincinnati | Questionable | thigh |
| Brandon McGowan | S | 09/04/2010 | is on injured reserve | IR | chest |
| Darryl Richard | DT | 08/31/2010 | is on injured reserve | IR | foot |
| Bret Lockett | DB | 08/31/2010 | is on injured reserve | IR | chest |
| Josh Barrett | S | 08/31/2010 | is on injured reserve | IR | shoulder |
| Leigh Bodden | CB | 08/31/2010 | is on injured reserve | IR | shoulder |
| Torry Holt | WR | 08/15/2010 | is on injured reserve | IR | knee |
| Ty Warren | DT | 08/13/2010 | is on injured reserve | IR | hip |
| |
| New York Jets |
| Player | Pos. | Date | Details | Status | Injury |
| Shaun Ellis | DE | 09/09/2010 | is questionable for Monday's game against Baltimore | Questionable | knee |
| Brodney Pool | S | 09/09/2010 | is questionable for Monday's game against Baltimore | Questionable | ankle |
| Calvin Pace | LB | 08/31/2010 | is expected to miss 4-6 weeks | Out | foot |
| Ropati Pitoitua | DE | 08/22/2010 | is on injured reserve | IR | Achilles |
| Santonio Holmes | WR | 05/22/2010 | will be eligible to return on 10/11 against Minnesota | Suspended | four-game suspension |
| |
| Oakland Raiders |
| Player | Pos. | Date | Details | Status | Injury |
| Travis Goethel | LB | 09/08/2010 | is questionable for Sunday's game against Tennessee | Questionable | back |
| Walter McFadden | CB | 09/08/2010 | is questionable for Sunday's game against Tennessee | Questionable | hamstring |
| Desmond Bryant | DT | 09/08/2010 | is questionable for Sunday's game against Tennessee | Questionable | elbow |
| Michael Bush | RB | 09/10/2010 | is questionable for Sunday's game against Tennessee | Questionable | thumb |
| Chaz Schilens | WR | 08/25/2010 | is out indefinitely | Out | knee |
| Luke Lawton | FB | 07/12/2010 | will be eligible to return on 9/26 against Arizona | Suspended | two-game suspension |
| |
| Pittsburgh Steelers |
| Player | Pos. | Date | Details | Status | Injury |
| Chris Kemoeatu | G | 09/09/2010 | is questionable for Sunday's game against Atlanta | Questionable | foot |
| Byron Leftwich | QB | 09/03/2010 | is expected to miss 2-4 weeks | Out | knee |
| Chris Scott | T | 08/31/2010 | is on the Physically-Unable-to-Perform-List | PUP | foot |
| Willie Colon | T | 07/21/2010 | is on injured reserve | IR | Achilles |
| Limas Sweed | WR | 05/11/2010 | is on injured reserve | IR | Achilles |
| Ben Roethlisberger | QB | 09/03/2010 | will be eligible to return on 10/17 against Cleveland | Suspended | four-game suspension |
| |
| San Diego Chargers |
| Player | Pos. | Date | Details | Status | Injury |
| Shawne Merriman | LB | 09/09/2010 | is doubtful for Monday's game against Kansas City | Doubtful | Achilles |
| Donald Butler | LB | 08/31/2010 | is on injured reserve | IR | Achilles |
| Vincent Jackson | WR | 07/01/2010 | will be eligible to return on 10/3 against Arizona | Suspended | three-game suspension |
| |
| Tennessee Titans |
| Player | Pos. | Date | Details | Status | Injury |
| Marcus Howard | DE | 08/15/2010 | is on injured reserve | IR | triceps |
| William Hayes | DE | 09/10/2010 | is questionable for Sunday's game against Oakland | Questionable | knee |
| Jacob Ford | DE | 09/08/2010 | is questionable for Sunday's game against Oakland | Questionable | back |
| Colin Allred | LB | 09/08/2010 | is questionable for Sunday's game against Oakland | Questionable | ankle |
| Leroy Harris | G | 09/08/2010 | is probable for Sunday's game against Oakland | Probable | ankle |
| Justin Gage | WR | 09/08/2010 | is probable for Sunday's game against Oakland | Probable | hand |
| Mike Otto | T | 09/08/2010 | is questionable for Sunday's game against Oakland | Questionable | knee |
| Tony Brown | DT | 09/08/2010 | is questionable for Sunday's game against Oakland | Questionable | knee |
| David Thornton | LB | 09/03/2010 | is on the Physically-Unable-to-Perform-List | PUP | hip |
| Stafon Johnson | RB | 08/18/2010 | is on injured reserve | IR | ankle/fibula |
| Rod Hood | CB | 06/14/2010 | is on injured reserve | IR | knee |
| Gerald McRath | LB | 06/14/2010 | will be eligible to return on 10/10 against Dallas | Suspended | four-game suspension |
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